The association between enema and nervous system injury in Diquat poisoning.

This study aimed to explore the potential link between enema administration and nervous system injury in patients with diquat poisoning. To achieve this, the researchers conducted a population-based case-control analysis, collecting medical records of patients admitted to the hospital between January 2018 and January 2024. The case group consisted of patients who experienced central nervous system injury symptoms following diquat poisoning, while the control group comprised patients who did not exhibit such symptoms. The control group was matched 1:2 with the case group, resulting in a total of 101 patients with nervous system injury and 202 patients without. The researchers used conditional logistic regression models to analyze the data and identify potential associations. The study's findings suggest that enema administration may be associated with an increased risk of nervous system injury in patients with diquat poisoning. Specifically, the results showed that patients who underwent 2 or ≥3 enemas had significantly higher odds ratios (ORs) of nervous system injury, with ORs of 3.084 and 4.693, respectively, compared to those who did not receive any enemas. Notably, further analysis of age subgroups revealed that the risk was particularly elevated among patients aged 60 years or older. In this subgroup, the ORs of conducting 2 and ≥3 enemas were dramatically higher, with values of 10.184 and 14.982, respectively. These findings led the researchers to conclude that enema administration may be associated with an increased risk of nervous system injury caused by diquat poisoning, especially among older adults. The study's results highlight the potential need for caution when administering enemas to patients with diquat poisoning, particularly in elderly populations. Link: https://pubmed.ncbi.nlm.nih.gov/40382423/