Latest Articles and News - Jun 25, 2025
post on 25 Jun 2025
Utilizing Naloxone Education to Reduce the Mortality and Morbidity Rate of Overdose Deaths Within Opioid-Exposed Populations.
While efforts are being made to reduce opioid overdose fatalities, there is a need to equip individuals to act in overdose emergencies in an effort to slow the increasing rates of preventable opioid-related deaths in the United States. This study sought to determine whether education on naloxone administration would increase confidence in individuals utilizing harm reduction services to intervene in the presence of an opioid overdose. Methods: A cross-sectional study was conducted that included adult participants attending Challenges, Inc., a mobile harm reduction service site. Participants completed a baseline survey assessing their level of comfort and experience with naloxone administration. An optional standardized educational session focusing on proper naloxone use followed, and all participants were offered free naloxone. Participants completed a post-survey reassessing their confidence and willingness to administer naloxone. Results: Of the 100 participants, 75% reported witnessing at least one opioid overdose, with the majority of those seeing 10 or more opioid overdoses. Additionally, 58% of respondents had previously administered naloxone treatment, on average between one and four times. A significant increase was found in participants' confidence level of administering naloxone following the educational session (p < 0.0001). When asked about the likelihood of intervening when witnessing an opioid overdose, 96% agreed or strongly agreed that they would administer naloxone treatment. Conclusion: A single education session increased the confidence, willingness, and comfort of individuals in administering naloxone in the presence of an opioid overdose. Ultimately, improving naloxone education and access could lead to a decrease in morbidity and mortality in association with opioid-related overdoses.
https://pubmed.ncbi.nlm.nih.gov/40557007/Mg-Ion-Promoted Resistance and Regeneration Ability of Cu/SSZ-13 Catalysts against Phosphorus Poisoning for Selective Catalytic Reduction of NOx.
The SSZ-13 zeolite-supported Cu (Cu/SSZ-13) is a commercial catalyst for ammonia selective catalytic reduction (NH3-SCR), but it faces challenges such as phosphorus poisoning in practical applications. Despite extensive investigations into how phosphorus poisoning leads to the deactivation of Cu/SSZ-13, effective strategies for regenerating catalysts with high phosphorus loading poisoned under practical conditions remain underdeveloped. In this study, we propose that incorporating Mg ions into Cu/SSZ-13 zeolites can significantly enhance their resistance and regeneration ability against phosphorus poisoning. After hydrothermal aging at 650 °C, the NH3-SCR activity of phosphorus-poisoned Cu/SSZ-13 catalysts with high phosphorus loading (0.6 mmol/gcat) cannot be effectively restored; however, the addition of Mg enables nearly complete recovery of their activity. Combining advanced microscopy evidence with complementary spectroscopy results, we reveal that Mg ions occupy the Brønsted acid sites in the six-membered rings (6-MRs) of SSZ-13, which regulates the distribution of subsequently introduced Cu ions while enhancing the stability of Cu2+ and the framework Al of SSZ-13, inhibiting the aggregation of Cu species after phosphorus poisoning and thereby improving resistance. Furthermore, the preservation of the SSZ-13 framework also effectively facilitates the redispersion of Cu species after hydrothermal aging, significantly restoring NH3-SCR performance.
https://pubmed.ncbi.nlm.nih.gov/40556576/Normal physiologic carboxyhemoglobinemia of neonate masquerading as carbon monoxide poisoning.
Carbon monoxide toxicity is a common concern in emergency departments. This case report describes a neonate with a falsely elevated carboxyhemoglobin level, initially raising concern for carbon monoxide exposure. The neonate was transferred to a tertiary care hospital and admitted, with hyperbaric oxygen therapy considered. Ultimately, it was determined that actual carbon monoxide exposure was unlikely, and the elevated carboxyhemoglobin was attributed to natural breakdown of fetal hemoglobin by heme oxidase. This case highlights the importance of considering this physiological phenomenon when evaluating elevated carboxyhemoglobin levels in neonates. Recognizing this led to the deferral of hyperbaric oxygen therapy, reducing unnecessary resource utilization and preventing undue stress for the family.
https://pubmed.ncbi.nlm.nih.gov/40555583/
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