[Intoxication with a nitazene; new potent synthetic opioids on a rise].

The emergence of nitazenes, a class of highly potent synthetic opioids, has become a significant public health concern in Europe. These substances can cause severe and potentially life-threatening intoxications, even in small dosages. A recent case reported in the Netherlands highlights the dangers of nitazenes, specifically isotonitazepyne. A 60-year-old male with a history of substance use disorder experienced a near-fatal overdose after nasally ingesting self-prepared isotonitazepyne, resulting in respiratory and cardiac arrest. This case is notable as it represents the first reported instance of nitazene intoxication in the Netherlands, and it underscores the need for increased awareness and vigilance regarding these potent substances. The case also highlights the importance of prompt and effective treatment in managing nitazene overdoses. The patient's condition was reversed with the administration of naloxone, which is a standard treatment for opioid toxicity. However, it is essential to note that nitazene intoxications tend to have a more severe course than traditional opioid overdoses due to their high potency. As a result, treatment typically involves supportive care in addition to naloxone. The report emphasizes the importance of collaboration and reporting in managing emerging psychoactive substances like nitazenes. As their presence in Europe continues to grow, it is crucial for healthcare professionals and public health officials to be aware of the clinical presentation and management of nitazene overdoses. By sharing knowledge and best practices, it is possible to mitigate the risks associated with these potent substances and provide effective care for those who are affected. Link: https://pubmed.ncbi.nlm.nih.gov/40191915/