PFAS: The Forever Chemicals Hiding in Your Drinking Water

Omid Mehrpour
Post on 25 Jul 2025 . 14 min read.
Omid Mehrpour
Post on 25 Jul 2025 . 14 min read.
PFAS, also known as forever chemicals, are detected in the blood of 97% of Americans. The Centers for Disease Control and Prevention confirmed this through the National Health and Nutrition Examination Survey. These synthetic substances affect more than our bodies - they contaminate at least 45% of America's tap water.
The situation becomes more alarming because PFAS comprise nearly 15,000 different synthetic chemicals that can spread through water, soil, air, and food. Exposure to these persistent compounds above certain levels leads to serious health risks, including higher chances of prostate, kidney, and testicular cancers. The contamination reaches far beyond residential areas. The Department of Defense has identified 723 military installations where water might contain released PFAS chemicals. These substances have emerged as one of our most critical environmental health challenges as we examine their effects on the human body and their widespread presence.
Like microplastics, PFAS are part of a broader crisis of synthetic pollutants accumulating in human tissues.
Learn more about microplastics in the human body and their health impacts.
"PFAS have the potential to be a health concern because they don't break down easily and can stay in the environment and in the human body for a long time (which is why they are sometimes referred to as 'forever chemicals')." — American Cancer Society, Leading cancer research and advocacy organization
The 1950s saw PFAS take off commercially after manufacturers found their valuable properties. These chemicals first appeared in nonstick cookware, such as Teflon, before spreading to many other uses. Scientists discovered the first form, polychlorotrifluoroethylene (PCTFE), in 1934 [1]. They stumbled upon polytetrafluoroethylene (PTFE) in 1938, which was later commercialized as Teflon in 1945 [1]. World War II proved that these chemicals were highly effective for military use. They later spread to consumer products over the next few decades.
These chemicals now exist in thousands of forms and show up in many household items we use every day. PFAS appear in:
Water-resistant clothing, umbrellas, and tents
Nonstick cookware and kitchen utensils
Food packaging (pizza boxes, microwave popcorn bags, takeout containers)
Stain-resistant carpets and furniture
Personal care products (shampoo, dental floss, cosmetics)
Electronics and smartphones
PFAS have also been part of firefighting foams at military bases, airports, and firefighting training facilities since the 1970s [2].
PFAS's incredible durability stems from its chemical structure, specifically the carbon-fluorine bond. This bond ranks as one of the strongest known chemical bonds (485 kJ/mol) [3]. It's much stronger than other common bonds in nature, which makes PFAS very hard to break down in normal environmental conditions. These chemicals can last thousands of years once they enter our environment. They move through water systems and build up in soil, wildlife, and humans [4].
Similarly, nanoplastics—a smaller class of plastic pollutants—also persist in the environment and may travel even further due to their nanoscale size.
The Centers for Disease Control and Prevention found PFAS in the blood of 97% of Americans tested [5]. Production of certain PFAS types (PFOS and PFOA) dropped after 2002. Blood levels have slowly decreased since then - PFOS levels fell by 85% and PFOA by 70% between 1999-2000 and 2018-2019 [5]. New PFAS compounds are continually replacing the phased-out chemicals, allowing them to persist in our environment and the human body.
PFAS, known as forever chemicals, contaminate drinking water through multiple routes from manufacturing plants to household taps. These contamination paths help explain why PFAS chemicals have become systemic problems in water supplies across the United States.
A similar pattern is seen with microplastic pollution, where plastic particles contaminate water through runoff, packaging degradation, and wastewater treatment discharge.
Aqueous film-forming foam (AFFF) is a significant source of PFAS contamination in drinking water. Military installations, airports, and industrial facilities have used this specialized firefighting foam extensively since the 1970s to suppress flammable liquid fires [6]. The Department of Defense has identified more than 700 military installations with potential PFAS leaching into soil or groundwater [7]. Testing has confirmed PFAS contamination of drinking water or groundwater at 167 of these sites on or near the bases [8].
Manufacturing facilities release PFAS through wastewater discharge, air emissions, and waste disposal during the production and use processes. Chemical manufacturing plants, semiconductor factories, textile mills, and paper manufacturing facilities represent major industrial sources [9]. Centralized waste treatment centers and landfills that receive PFAS-containing waste add to this contamination cycle [10]. PFAS can seep into surrounding soil and reach groundwater supplies as waste decomposes.
PFAS behave differently from other contaminants. These chemicals bind to soil particles and release gradually over time, rather than washing away quickly [11]. This creates persistent contamination sources that seep into groundwater for decades. A U.S. Geological Survey study found that at least one type of PFAS could exist in nearly half of America's tap water [12]. PFBS, PFHxS, and PFOA emerge as the most commonly detected compounds [13].
Many homeowners do not realize that their plumbing systems can contain PFAS. Firefighting foam has accidentally backflowed into residential plumbing systems in several documented instances (Wyoming, OH in 2018; Neville Island, PA in 2019; Westmoreland County, PA in 2020). [14]. Studies show that pumping these chemicals may resurface after a period of dormancy because they gradually dissolve from the pipe, but flushing can reduce PFAS concentrations by up to 99.95% 99.99%. [15].
Our bodies are constantly at war with PFAS, and this becomes concerning when we examine their health effects. These chemicals don't just pass through our system; they accumulate and interfere with important biological functions.
Microplastics and nanoplastics show similar behavior, crossing biological barriers and accumulating in organs such as the brain, lungs, and placenta.
Research shows that exposure to PFAS, especially PFOA and PFOS, leads to increased risk of kidney and testicular cancers [16]. Studies also point to possible links with thyroid cancer, though scientists need to do more research to confirm this [17].
The scariest part might be how PFAS weakens our immune system by a lot. Kids exposed to PFOA show weaker immune responses to tetanus vaccines, while PFOS exposure cuts down antibody production after diphtheria vaccination [18]. Immune suppression—especially reduced vaccine antibody response—is considered one of the most sensitive and well-established effects of PFAS exposure [19].
PFAS function as endocrine-disrupting chemicals and have been linked to altered levels of reproductive hormones like testosterone and estradiol [20]. They disrupt normal reproductive function by altering hormone production, menstrual cycles, and fertility [21]. Maternal exposure to PFOA and other PFAS has been associated with reduced sperm concentration and total sperm count in adult sons [18].
Kids exposed to PFOA have shown associations with developmental delays, but links to autism spectrum disorder remain inconclusive [22]. This affects brain development during crucial growth periods.
PFAS exposure has been associated with increased risk of metabolic liver changes, including fatty liver indicators, in both animal and human studies [4]. These chemicals trigger oxidative stress and inflammatory responses in liver cells [23]. These toxic effects mirror the oxidative and inflammatory damage linked to microplastic exposure in multiple human organs.
Higher PFOA levels have been linked to delayed pubertal onset in girls, though findings vary by sex and exposure timing [24]. This creates bone health issues down the road since PFOS exposure links to weaker bone density [25].
Government agencies, scientists, and communities are taking decisive steps to tackle PFAS contamination, which has become a systemic problem.
The EPA has proposed the first-ever national drinking water standard that covers six PFAS compounds. Public water systems must monitor these chemicals and reduce them to the lowest technically feasible levels under this regulation. The new limits are 4 parts per trillion for PFOA and PFOS, which are by a lot stricter than previous health advisories.
Scientists have developed several promising filtration methods. Granular activated carbon, ion exchange resins, and high-pressure membranes remove various PFAS compounds from drinking water effectively. Research teams are also working on destruction techniques like electrochemical oxidation and supercritical water oxidation that can break the stubborn carbon-fluorine bonds.
Local advocacy has driven important changes across the country. Community pressure in Michigan led to complete statewide testing that revealed many contamination sites officials didn't know about before.
You can protect yourself by:
Installing certified water filters (look for NSF/ANSI 53 or P473 certification)
Asking for a water quality report from your utility
Getting your home tested through certified laboratories
You can make a difference by reaching out to elected officials to strengthen PFAS regulations and support the PFAS Action Act. Your voice matters at public meetings about local water quality. Join community groups that fight for clean water initiatives.
PFAS in our drinking water is one of today's most important environmental health challenges. These "forever chemicals" came into use in the 1930s and became common after the 1950s. They now pose a threat to water systems everywhere because they don't break down easily. Their carbon-fluorine bond makes them last for thousands of years, and they ended up building up in our environment and bodies.
The PFAS problem has reached dangerous levels. These chemicals are found in 97% of Americans and contaminate almost half of our tap water. The health risks are just as worrying. Research shows that exposure to PFAS leads to higher cancer risks, weaker immune systems, hormone problems, slower development, and liver damage.
The situation looks tough, but we're making progress. The EPA wants to set strict national drinking water limits for six PFAS compounds. New filtration methods are a great way to get these chemicals out of water supplies. Local communities have also pushed for vital testing and cleanup work in cities and towns.
We can all help fight PFAS contamination. People should test their home water, put in certified filters, and push for tougher rules. We need to tackle these industrial chemicals that have quietly seeped into our water for decades.
Clean water should be everyone's right, not just a privilege. Scientists keep learning more about PFAS risks every day. Our response needs to match how big this problem really is. The health of our communities tomorrow depends on what we do about these forever chemicals today.
PFAS are just one piece of the broader pollution puzzle. Explore how microplastics and nanoplastics are also threatening our environment and bodies—with equally urgent consequences.
PFAS "forever chemicals" are found in 97% of Americans' blood and nearly half of US tap water, creating an urgent public health crisis that demands immediate attention and action.
• PFAS persist for thousands of years due to ultra-strong carbon-fluorine bonds, accumulating in water, soil, and human bodies without breaking down naturally.
• These chemicals increase cancer risks, suppress immune systems, disrupt hormones, and cause developmental delays in children through widespread contamination.
• Major contamination sources include firefighting foams at military bases, industrial waste, and manufacturing runoff that seeps into groundwater systems.
• Protect yourself by installing NSF-certified water filters, testing your home water supply, and supporting stricter EPA regulations for drinking water standards.
• Community advocacy drives policy change - contact elected officials and join local clean water initiatives to combat this environmental health threat.
The fight against PFAS contamination requires both individual action and collective advocacy. While new EPA regulations and filtration technologies offer hope, protecting our water supply ultimately depends on sustained public pressure and policy reform at all levels of government.
PFAS are a group of synthetic chemicals that have been used in various consumer products since the mid-1950s. A common explanation suggests that their rapid adoption was due to their effectiveness, and they are still in use today. PFAS are referred to as "forever chemicals" because they do not readily break down in the environment or within the body. They persist for thousands of years due to the stability of their strong chemical structure.
PFAS enter drinking water from many sources, including industrial waste, firefighting foams used on military bases and airports, contaminated soil and groundwater, and treated plumbing systems in homes. PFAS can migrate through water sources, move laterally in receiving bodies of water, or gradually accumulate over time in the environment.
PFAS exposure may increase certain health problems, such as specific cancers (kidney, testicular, and thyroid), immune suppression, hormone disruptions, delayed development in children, liver damage, impaired bone density, and a delayed onset of puberty.
Ways to reduce exposure include: knowing your water filter's certification (look for NSF/ANSI 53 and/or P473); requesting your water quality report from your utility; testing your water at an accredited lab; staying informed about water quality issues in your area; and supporting efforts to improve water quality.
The EPA proposes a national drinking water standard for six PFAS chemicals, requiring public systems to test for and attempt to remove these compounds. New technologies for removing PFAS are being developed. Community-led cleanup initiatives are advocating for policy changes, and ongoing research seeks to develop methods for chemically degrading these substances without producing harmful byproducts.
PFAS can enter the body through the consumption of contaminated drinking water or food, inhalation of dust containing PFAS, and skin absorption from materials contaminated with PFAS.
Some PFAS can remain in the body for many years. PFOA and PFOS, for example, have half-lives of 2 to 9 years, causing them to accumulate in the blood and tissues over time.
Yes, PFAS can be reduced with advanced filtration methods such as activated carbon filters, reverse osmosis systems, and ion exchange filters. Look for treatment systems certified for PFAS removal, like NSF/ANSI 53 or 58.
Yes. Because children are smaller, still developing, and often have higher exposure per body weight, they are especially vulnerable. PFAS can affect growth, immune function, and hormone development in children.
There are no immediate symptoms. PFAS molecules can accumulate slowly, leading to health issues like hormonal disruptions and cancer, which develop over time.
Yes, blood tests are available in specialized laboratories, primarily for legal or research purposes. These tests indicate the amount of PFAS in your blood but do not directly link the levels to specific health effects.
The U.S. EPA is proposing maximum contaminant levels (MCLs) as low as 4 parts per trillion (ppt) for PFOA and PFOS. These standards are based on current research into health risks and policy decisions.
Yes. Many waterproof and long-wear cosmetics, including foundations, mascaras, and lipsticks, may contain PFAS as water-resistant ingredients.
Yes. PFAS exposure has been linked to decreased fertility, lower birth weights, pre-eclampsia, and developmental delays in infants.
Yes. Lawsuits have been filed against manufacturers such as DuPont and 3M, resulting in multi-billion-dollar settlements related to water contamination, health risks, and ongoing damages due to exposure.
PFAS are just one piece of today’s toxic exposure crisis. At MedicalToxic.com, we break down complex environmental and drug-related health risks into clear, actionable insights.
👉 Explore our most-read blogs:
Microplastics in the Human Body: The Hidden Threat to Our Health
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Microplastic Pollution: A Growing Threat to Our Environment and Health
Understand the origins and effects of microplastic contamination in water, soil, and food.
Nanoplastics and Human Health: The Invisible Threat Beyond Microplastics
Learn how nanoplastics cross biological barriers and affect your organs—including the brain.
© All copyright of this material is absolute to Medical toxicology
Dr. Omid Mehrpour (MD, FACMT) is a senior medical toxicologist and physician-scientist with over 15 years of clinical and academic experience in emergency medicine and toxicology. He founded Medical Toxicology LLC in Arizona and created several AI-powered tools designed to advance poisoning diagnosis, clinical decision-making, and public health education. Dr. Mehrpour has authored over 250 peer-reviewed publications and is ranked among the top 2% of scientists worldwide. He serves as an associate editor for several leading toxicology journals and holds multiple U.S. patents for AI-based diagnostic systems in toxicology. His work brings together cutting-edge research, digital innovation, and global health advocacy to transform the future of medical toxicology.
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