ApapToxApapToxApapTox is a web-based clinical decision support system that combines traditional Rumack-Matthew Nomogram analysis with lab-guided risk assessment to optimize the management of acetaminophen overdose, including delayed and repeated ingestions.
May 1, 2025Updated
1.0.0Version
FreePricing
100+Users
• About
Dual-Mode Risk Stratification
Dual-Mode Risk Stratification Assesses risk using nomogram-based (4–24h) and laboratory-based logic for delayed cases.
RSTI Management Support
RSTI Management Support Supports repeated supratherapeutic ingestion (RSTI) scenarios with cumulative dose evaluation.
Smart NAC Dosing Automated
Smart NAC Dosing Automated, weight-based N-acetylcysteine (NAC) dosing with dynamic adjustment for lab trends.
Hemodialysis & Transplant Guidance
Hemodialysis & Transplant Guidance Integrates EXTRIP & King's College Criteria for dialysis/transplant alerts.
Frontend-driven Real-Time Engine
Frontend-driven, Real-Time Engine with Fully client-side logic for instant feedback and compliance with CDS regulations.
EHR Integration
EHR Integration Ready HL7/FHIR-based integration planned for seamless hospital workflow.
• Changelog
Version 1.0.0
• Initial release of the product
• FAQ
Who can use ApapTox?
Emergency physicians, toxicologists, intensivists, and clinical pharmacists managing acetaminophen toxicity cases.
Does ApapTox handle late-presenting or unclear overdose cases?
Yes. ApapTox evaluates lab biomarkers (ALT, INR, pH, lactate, etc.) for late presentations or when serum APAP is undetectable.
Is ApapTox suitable for RSTI cases?
Yes. It incorporates cumulative dose and patient-specific risk factors to support NAC initiation in RSTI.
Does it offer NAC dosing suggestions?
Absolutely. ApapTox generates weight-adjusted dosing protocols and determines when NAC can be safely stopped.
Can it be integrated into hospital systems?
Integration via HL7/FHIR protocols is under development for EHR support.
Is it FDA-regulated?
It qualifies as a non-device CDS per the 21st Century Cures Act. Future AI versions may fall under FDA Class II.
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