Fifty-Four Tablets Too Many: A Case Report of Amlodipine and Losartan Overdose.

The misuse or overdose of certain cardiovascular medications, specifically calcium channel blockers and angiotensin receptor blockers, can lead to severe and potentially life-threatening complications. These medications are commonly used to treat conditions such as high blood pressure and heart disease, but when taken in excess, they can cause significant hemodynamic instability. This means that the body's blood pressure and circulation can become severely disrupted, leading to a range of serious symptoms, including cardiac arrhythmias, hypotension, and even organ failure. Effective management of such overdoses requires prompt and aggressive intervention. One key approach is the use of hyperinsulinemia-euglycemia therapy, which involves administering high doses of insulin to help stabilize the body's cardiovascular system. Additionally, vasopressors may be used to constrict blood vessels and increase blood pressure, while calcium gluconate can help to counteract the effects of the overdose on the heart and blood vessels. However, treatment does not stop there. It is also essential to provide long-term care and support to individuals who have overdosed, including psychological evaluation and counseling to address any underlying factors that may have contributed to the overdose. By taking a comprehensive and multifaceted approach to treatment and prevention, healthcare providers can help to reduce the risk of recurrence and promote better overall health outcomes for individuals who have experienced a cardiovascular medication overdose. Link: https://pubmed.ncbi.nlm.nih.gov/40270776/