Toxidrome | Clinical Effects–Based Diagnosis Calculator

Toxidrome is designed for poison center specialists, medical toxicologists, emergency clinicians, ICU teams, hospitalists, trainees, and pharmacists evaluating suspected poisoning when the agent is unknown or mixed.

You’ll need bedside clinical findings: pupil size/reactivity, mental status pattern, neuromuscular findings (e.g., clonus/rigidity), vital sign trends, skin findings (dry/diaphoretic), bowel/urinary findings when relevant, and basic cardiopulmonary exam features. The tool works best when findings are based on current exam, not anticipated effects.

No. It supports pattern recognition and differential prioritization. Final diagnosis depends on clinical judgment, confirmatory testing, exposure history, and response to treatment.

Toxidrome is primarily a diagnostic support tool. If you later add prompts (e.g., suggested confirmatory tests or critical actions), they should be treated as decision support, not prescriptive orders. Final management decisions remain with the treating team and local protocols.

Use caution. Mixed intoxication, co-withdrawal, delirium, sedatives, hypoxia/hypercapnia, sepsis, and primary neurologic disease can produce overlapping patterns. In these cases, the tool is best used to structure reassessment and highlight discriminating findings, not to “pick a winner.”

Overweighting a single finding (e.g., delirium or tachycardia), ignoring confounders (sedation/intubation), and assuming absent findings weren’t assessed. The “missing high-yield” list is most useful when it triggers a deliberate re-check.